Hypo-allergenic / No Allergy
Hypoallergenic cosmetics are formulated to minimize the risk of allergic reactions by using fewer potential irritants and allergens. These products are designed for sensitive skin and aim to reduce the likelihood of adverse reactions. However, “hypoallergenic” does not guarantee that a product will be completely free of allergens. It’s still important to test new products to ensure compatibility with your skin.
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| IgE Binding Assay | Binds to allergens and triggers histamine release from mast cells and basophils, leading to allergic responses. | Non-Hypoallergenic |
| Basophil Activation Test | Measures degranulation of basophils, which release histamine and other mediators in response to allergens, indicating allergic potential. | Hypoallergenic or non-sensitizing |
| TNF-α | Triggers systemic inflammation by activating NF-κB signaling and inducing apoptosis in affected cells. | Minimal skin irritation. |
| IL-1α and IL-6 | Promotes inflammation and stimulates the production of acute-phase proteins in response to infection or injury. | Reduced inflammation or irritation. |
| MTT | Reflects cellular metabolic activity, where viable cells convert MTT to a formazan product, indicating intact mitochondria. | Non-cytotoxic or safe for skin. |
| LDH | Released into the extracellular space when cell membranes are damaged, indicating cytotoxicity or cell lysis. | Non-cytotoxic. |
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Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)