Anti Aging Claim Panel
In addition to being a natural part of aging, wrinkles also arise from external factors such as sun damage, pollution, stress, and fatigue. These elements degrade both dermal and epidermal skin components, leading to a gradual breakdown of the skin barrier. As a result, the skin surface alters, losing its youthful appearance and taking on an older, more aged look.
Why wrinkles appear
Over time, skin loses its natural moisture and the dermal-epidermal skin junction gradually loses its cohesion. As skin cells receive less nutrients, their production of structural proteins slows down. As these proteins become rare or damaged, skin loses tonicity and firmness. Expression wrinkles result from muscular action. Microcontractures generate lines and the skin between these lines distends. The areas that are most prone to changes in expression (forehead, eyebrows, lips) show these types of wrinkles. The folds of distended skin are another sign of loss in skin tone and firmness.
| Test Menu |
|---|
| Collagen Production |
| Skin Firmness and Elasticity |
| Rejuvenating / Regeneration / Anti-Age Spots |
Cream
Serums
Face Mask
Soap
Face Oil
Biomarker Testing List:
| Biomarker | Remarks on the Biomarker |
|---|---|
| Matrix Metalloproteinase-1 (MMP-1) | Enzymes that degrade extracellular matrix components, playing a critical role in tissue remodeling and repair processes. |
| Matrix Metalloproteinase-3 (MMP-3) | The predominant collagen in skin, bones, and connective tissues, providing structural strength and support. |
| Matrix Metalloproteinase-8 (MMP-8) | Provides elasticity and support, often found alongside type I collagen in tissues, particularly during wound healing. |
| Matrix Metalloproteinase-9 (MMP-9) | An enzyme that breaks down extracellular matrix components, involved in tissue remodeling, inflammation, and the immune response. |
| Collagen Type I | A protein that allows tissues to resume their shape after stretching or contracting, crucial for skin and vascular health. |
Reference Research Publications:
- Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
- Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
- The anti-wrinkles properties of sodium acetylated hyaluronate
- Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
- Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
- Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects
- Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
- An Efficient Means to Mitigate Skin Inflammaging by Inhibition of the NLRP3 Inflammasome and Nfkb Pathways: A Novel Epigenetic Mechanism
Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
Conceptualization, S.J., H.L., C.L., H.J.C., J.K. and H.J.K.; Investigation, S.Y, S.K., J.J., M.K., K.S., H.S.H., and K.-Y.P.; Writing-Original Draft Preparation, S.J.; Writing-Review & Editing, C.L. and H.J.K.; Project Administration, H.J.K.
International Journal of Molecular Science
Submission received: 6 November 2019 / Revised: 15 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019
https://doi.org/10.3390/ijms21010073
Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
Wannita Klinngam a 1, Phetploy Rungkamoltip a 1, Saowarose Thongin a, Jaruwan Joothamongkhon a, Phattharachanok Khumkhrong a, Mattaka Khongkow a, Katawut Namdee a, Surapun Tepaamorndech b, Puxvadee Chaikul c d, Mayuree Kanlayavattanakul c d, Nattaya Lourith c d, Kitiya Piboonprai a e, Uracha Ruktanonchai a, Udom Asawapirom a, Tawin Iempridee
Volume 145, January 2022, 112461
https://doi.org/10.1016/j.biopha.2021.112461
The anti‐wrinkles properties of sodium acetylated hyaluronate
Journal of cosmetology
Marie Meunier, Amandine Scandolera PhD1 Emilie Chapuis BS1
Received: 2 August 2021 Revised: 14 September 2021 Accepted: 27 September 2021
Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
Dermatology and theraphy
Published online 2020 Jan 3.
Mridvika Narda, 1 Anthony Brown,2 Béatrice Muscatelli-Groux,3 Jean A. Grimaud,3 and Corinne Granger