Skin sensitivity is characterized by an abnormally strong response to external stimuli, including cosmetic ingredients, environmental factors, and allergens. Usually, the establishing hyperresponsivenes of skin irritation is linked with compromise of skin barrier, leading to an increased water loss and irritant susceptibility. Signs of sensitive skin may include redness, dryness, itching, or burning. The mechanisms underpinning all these include immune-mediated inflammation and neurogenic responses. Some typical triggers of skin sensitivity are UV exposure, pollution, and contact with certain chemicals, leading to oxidative stress and inflammation.

Dermatological processes such as TEWL measurement, profiling of cytokines, and enhanced in vitro models provide critical information to ascertain and attenuate sensitivity to pave a way for the formulation of products that are efficient yet gentle for skincare.