Anti-Photoaging / SPF Aging
Protecting skin from UV-induced photo-aging is essential. Photo-aging refers to the premature aging of the skin caused by repeated exposure to UV rays from the sun or artificial sources. UV rays can damage the skin’s structure, leading to signs such as fine lines around the eyes and mouth, forehead expression lines, pigmentation spots, uneven complexion, and a loss of skin tone. These aging signs can appear prematurely due to UV exposure.
To address the increasing demand for ingredients that repair and protect against UV damage, many anti-photoaging ingredients are available with with proven biological activity, tested using advanced technology. We validate the cosmetic actives’ effectiveness through rigorous laboratory testing on reliable 3D tissue models.
Cosmetic Products
Milk Sunscreen SPF 100
Wrinkle Repair Retinol Oil
Sunscreens
UV Clear Broad-Spectrum SPF 46
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| MMP8 | It is involved in processes like wound healing, tissue remodeling, and the immune response. | reducing wrinkle formation |
| (8-OHdG) | . Accumulation of 8-OHdG is linked to aging, cancer, and other degenerative diseases. | Antioxidant protection |
| 1α (IL-1α) | promoting the immune cells to the site of inflammation, and stimulating the production. | treatment of acne or dermatitis |
| MMP1 | process crucial for normal tissue remodeling, wound healing, and angiogenesis. | improving skin firmness. |
| 6 (IL-6) | pro-inflammatory cytokines that play significant roles in the immune response, inflammation, and aging processes within the skin. | skin-calming, anti-aging treatment |
Scientific Driven with our Technology:
Using our expertise in immunology and cell culture, we develop immunoassays based on ELISA principle. Using cutting edge tools like 3D tissues (some of which are OECD approved for skin / cornea irritation), we bring the human experimentation into the labs. Curating a list of research publications, we have developed a platform to test products for their biomarkers mimicking the human model to generate data to back our label claims.
Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)
Reference Research Articles:
Protection against UV – Explosure
- A human skin model to evaluate the protective effect of compounds against UVA damage
- Melatonin, bakuchiol and ascorbyl tetraisopalmitate synergize to modulate gene expression and restore Hypoxia-Inducible Factor 1 signaling in UV-exposed skin
- Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation
- SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
- Integrating targeted gene expression and a skin model system to identify functional inhibitors of the UV activated p38 MAP kinase
- Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo
- A human skin model to evaluate the protective effect of compounds against UVA damage
- International Journal of Cosmetic Science
- Abadie, P. Bedos, J. Rouquette
- First published: 12 September 2019
- https://doi.org/10.1111/ics.12579
- Cellular and Molecular Biology
- Issue Published : January 15, 2020
- https://www.cellmolbiol.org/index.php/CMB/article/view/3345
- Cellular and Molecular Biology, Vol. 65 No. 8: Issue 8
Article Published :December 31, 2018 - Melatonin, bakuchiol and ascorbyl tetraisopalmitate synergize to modulate gene expression and restore Hypoxia-Inducible Factor 1 signaling in UV-exposed skin
- SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
- Author details 1 School of Medical Science, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA 6027, Australia. 2 GENOSKIN Centre Pierre Potier, Oncopole, Toulouse, France. 3 School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA, Australia.
- Received: 2 December 2016 Accepted: 2 June 2017
- Published 10 june 2017.
- https://bmcdermatol.biomedcentral.com/counter/pdf/10.1186/s12895-017-0060-y.pdf
The roles of cytokines in photoaging
Journal of dermatological science
Seiji Kondo
10 April 2000