Well-Being
Well-being, a long term asset for cosmetics
Research indicates that end users purchase cosmetics primarily to enhance their own sense of well-being, a reason highlighted by participants. Consequently, skin and hair care products serve a dual purpose: they are both practical and emotionally fulfilling. Among these, the emotional aspect plays the most significant role in influencing consumers’ choices. Using effective products to boost personal well-being is a key motivation for self-care.
Research has indicated that skin cell longevity increases by activating the Klotho protein, which is known as the “youth protein”
Klotho is drawing increasing interest from cosmetic R&D departments and has enabled a better understanding of the aging process with a lot of manufacturers using the same.
By increasing the expression of Klotho in skin cells, it allows to preserve the skin from the natural aging process. Skin firmness is maintained and skin tone becomes more harmonious and radiant.
Cosmetic Products
Natural Foods
Cough Drops / Lozenges
Aromatherapy
Sleep-Enhancing Skincare
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| IL-6, TNF-alpha | pro-inflammatory cytokines that play significant roles in the immune response, inflammation, and aging processes within the skin. | anti-aging, and skin-calming effects |
| (CRP) | It is a marker of systemic inflammation produced in response to inflammatory cytokines. | treatment of inflammatory skin conditions. |
| IgA, IgG, IgM | The first antibody produced during an immune response, it forms pentamers that efficiently agglutinate pathogens and activate the classical complement pathway. | Immune-boosting, protection against infections |
| (MMP8) | It is involved in processes like wound healing, tissue remodeling, and the immune response. | Anti-aging, collagen protection |
| Cytokines | promoting the immune cells to the site of inflammation, and stimulating the production | wound healing, skin regeneration |
Scientific Driven with our Technology:
Using our expertise in immunology and cell culture, we develop immunoassays based on ELISA principle. Using cutting edge tools like 3D tissues (some of which are OECD approved for skin / cornea irritation), we bring the human experimentation into the labs. Curating a list of research publications, we have developed a platform to test products for their biomarkers mimicking the human model to generate data to back our label claims.
Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)
Reference Research Publications
Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group
ERA JOURNAL
Mehmet Kanbay, Sidar Copur, Lasin Ozbek, Ali Mutlu, Daniel Cejka, Paola Ciceri, Mario Cozzolino, Mathias Loberg Haarhaus
Published:
03 November 2023
https://doi.org/10.1093/ckj/sfad276
The versatility of klotho protein: insights into its multifaceted functions in health and disease.
world Journal of current medical and pharmaceutical research.
Sonali Raj, Mehak Ahuja
05-06-2024
https://doi.org/10.37022/wjcmpr.v6i2.328
Protein interaction networks characterizing the A549 cells Klotho transfected are associated with activated pro-apoptotic Bim and suppressed Wnt/β-catenin signaling pathway
Nature journal
Mitsuo Matsumoto, Naomi Ogawa, Tetsuya Fukuda, Yasuhiko Bando, Toshihide Nishimura & Jitsuo Usuda
Published: 25 January 2024