Anti- Dandruff
Dandruff is a common scalp condition caused by a variety of factors, including excess oil production, environmental stress (heat, UV rays, pollution), and microbial growth. These factors disrupt the natural balance of the scalp, leading to flaking, itching, and irritation.
Our anti-dandruff formula effectively targets these issues, restoring the scalp’s health and balance. By reducing excess oil, eliminating dandruff-causing microbes, and soothing irritation, our product ensures a flake-free, comfortable scalp, and healthy, vibrant hair.
Hair Mask
Shampoos
Hair Serums
Tea Tree Oil
Hair Powders
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| D4 (LTD4) | LTD4 is a potent pro-inflammatory mediator. | Calms reactive skin." |
| ( A4 (LTA4) | leukotriene involved in immune responses, especially neutrophil chemotaxis and activation. | Minimizes skin irritation |
| (TNF-α) | TNF-α is a pro-inflammatory cytokine involved in the NF-κB signaling pathway. It is produced by various cells, including macrophages and T cells, in response to infections, cancer, and other stress signals. | Reduces redness |
| CCL5 | CCL5 plays a role in various inflammatory diseases, including autoimmune conditions. | Reduces skin reactions |
| (IFN-γ) | IFN-γ is a cytokine involved in the JAK-STAT signaling pathway. It is primarily produced by T cells and natural killer (NK) cells in response to antigenic stimuli. | Modulates immune response |
Scientific Driven with our Technology:
Using our expertise in immunology and cell culture, we develop immunoassays based on ELISA principle. Using cutting edge tools like 3D tissues (some of which are OECD approved for skin / cornea irritation), we bring the human experimentation into the labs. Curating a list of research publications, we have developed a platform to test products for their biomarkers mimicking the human model to generate data to back our label claims.  Â
Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)
Reference Research Publications
Anti – Dandruff
Allergic contact dermatitis caused by dexpanthenol-Probably a frequent allergen.
Clinical efficacy of a gentle anti–dandruffitch-relieving shampoo formulation.
Anti–dandruffHair Tonic Containing Lemongrass (Cymbopogon flexuosus) Oil.
Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen
Contact Dermatitis
Rosa A. Fernandes, LuÃs Santiago, Miguel Gouveia, Margarida Gonçalo
First published: 16 July 2018
Randomized study comparing the efficacy and tolerance of a lipohydroxy acid shampoo to a ciclopiroxolamine shampoo in the treatment of scalp seborrheic dermatitis
Journal of cosmetic dermatology
First published: 25 November 2009
Biomarker for each cosmetic products to test
1)Shampoos
Biomarker : Leukotrienes( A4 (LTA4), B4 (LTB4), D4 (LTD4),E4Â Â Â Â Â Â (LTE4),Chemokine(CXCL8 (Interleukin-8),(CXCL12),CCL5,(C-C motif) ,ligand 2 (CCL2),Prostaglandin E2 (PGE2), Cytokines
2) Lotions
Biomarker : Interleukins (IL), Tumor Necrosis Factor-alpha,(MMPs),Chemokines, Nitric Oxide ,C-Reactive Protein, (VCAM-1), Nuclear Factor-kappa B
3) Ointments
Biomarker : Cytokines (IL-1, IL-6, TNF-alpha),C-reactive protein (CRP),Transepidermal Water Loss (TEWL),Filaggrin, (CXCL8 (Interleukin-8),(CXCL12),CCL5,Nuclear Factor-Erythroid 2-Related Factor 2 (NRF2) Pathway genes C-reactive protein (CRP)
4) Facial kits
Biomarker : MMP-1 (Collagenase-1),TIMPs (Tissue Inhibitors of Metalloproteinases),MMP-8 (Collagenase-2/Neutrophil – collagenease),Cytokines (e.g., IL-1, IL-6, TNF-alpha),ROS (Reactive Oxygen Species) Levels,Bacterial Taxa, 16S rRNA, PCR
5) Serums
Biomarker : Corneometry(skin hydration),TEWL (Transepidermal Water Loss),R6 (Biological Viscoelasticity),Ssk (Core Fluid Retention)
6) Soaps
Biomarker : Lipid Content Analysis (triglycerides), (TLC) , Acid Mantle,Buffering Capacity,Sebumeter,Cytokines (IL-1, IL-6, TNF-alpha)
7) Skin Dipegmintation
Biomarker : Immunohistochemistry (IHC),Tyrosinase Expression,Skin Colorimetry,C-Reactive Protein (CRP),Interleukin-6 (IL-6),Serotonin Transporter Occupancy,Acetylcholinesterase Activity,Tyrosine Kinase Activity.
8) Collagen Boost
    Biomarker : Collagen Type I Levels, Fructosyl-lysine, (MG-H1), (CML), (PINP), (CTX-I), (CTX),Matrix Metalloproteinases (MMPs),Hydroxyproline Levels, 8),Chemokines (e.g., CXCL8, CCL2), Interleukins, TNF-alpha, Interleukin-6 (IL-6)
9) UV Protection
Biomarker : 8-hydroxy-2′-deoxyguanosine (8-OHdG) ,glutathione, Superoxide dismutase (SOD), (TNF-alpha), CD4/CD8 ratio or cytokine
 10) Oral gingival care
            Biomarker : Calcium (Ca) and Phosphate (P) Levels,C-Reactive Protein (CRP),Interleukins (e.g. IL-6, IL-
11) Eye Cosmetic
Biomarker :  Ig gamma-2,sPLA2-IIa, Total protein,serum albumin precursor,Interleukin-1β, IL-6, IL-7, IL-13, IL-17A, IL-18, TNF-α, RANTES/CCL5, IFN-γ,α-1 antitrypsin,keratin (type I) putative LCN-1 like protein,IL-8, IFN-γ, MIP-1α, MIP-1β
12) Intimate area
Biomarker : Cytokines (IL-1, IL-6, TNF-alpha), (TEWL)
13) Nutraceuticals
Biomarker : Chemokines(CXCL8, CCL2) , C-reactive protein,  Beta-carotene, Chlorophyll a and b, Triglyceride Content, Polyunsaturated Fatty Acids (PUFAs)
14) Skin Depigmentation
Biomarker : MC1R (Melanocortin-1 Receptor),Tyrosin, L-DOPA, Hydroqunion, Cysteinyl DOPA, Pheomelanin, Depachrome , DHICA-Melanin,Eumelanius, Tyrosinase-related Protein 1 (TRP-1) and TRP-2,
15) Scar Removal
Biomarker : Collagen I , Collagen III, Elastin, Glycosaminoglycans (GAGs), IL-1 Receptor Antagonist (IL-1Ra), Metalloproteinases, Transforming Growth Factor-Beta (TGF-β), (VEGF), Anti-IL-6 (Interleukin-6), (DCT), (TRP-1)
16) Nail cosmetics
Biomarker : Cytokines (IL-1, IL-6), (MMPs),C-terminal telopeptide ,Hydroxyproline, (N-terminal propeptide of type I collagen, P1NP)
17) Miscelolanous Cosmetic
Biomarker : Specific IgE Antibodies,IL-4 and IL-13,IFN-γ, (HRIPT), Keratin 14 (K14), Vitamin C (ascorbic acid).
SCIENTIFIC REFERENCE FOR BIOMARKERS
IL-1 Receptor Antagonist (IL-1Ra)
Dinarello, C. A. (1996). Biologic basis for interleukin-1 in disease. Blood, 87(6), 2095-2147.
Arend, W. P., Malyak, M., Guthridge, C. J., & Gabay, C. (1998). Interleukin-1 receptor antagonist: role in biology. Annual Review of Immunology, 16(1), 27-55.
Chandran, S., & Tripathi, P. (2016). The role of IL-1 receptor antagonist in the treatment of rheumatoid arthritis. Clinical and Experimental Rheumatology, 34(2), 15-21.
Nuclear Factor-kappa B (NF-κB)
Karin, M., & Lin, A. (2002). NF-κB at the crossroads of life and death. Nature Immunology, 3(3), 221-227.
Gilmore, T. D. (2006). Introduction to NF-κB: players, pathways, perspectives. Oncogene, 25(51), 6680-6684.
Hayden, M. S., & Ghosh, S. (2008). Shared principles in NF-κB signaling. Cell, 132(3), 344-362.
Cytokines
Aggarwal, B. B., Gupta, S. C., & Kim, J. H. (2012). Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey. Blood, 119(3), 651-665.
Singh, V. K., Mehrotra, S., & Agarwal, S. S. (1998). The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy.
Godbole, G., & Sumantran, V. (2017). Cellular and molecular mechanisms in cancer immune escape: a comprehensive review. Expert Review of Clinical Immunology, 10(1), 41-62.
CD4/CD8 Ratio
Tripathy, S. P., Salvi, V. S., Paranjape, R. S., & Agnihotri, K. (2003). Immune activation and HIV disease progression: role of CD8+ T cell subsets.
Kumarasamy, N., Solomon, S., Flanigan, T. P., Hemalatha, R., Thyagarajan, S. P., Mayer, K. H., & Balakrishnan, P. (2003). Natural history of human immunodeficiency virus disease in southern India. Clinical Infectious Diseases, 36(1), 79-85.
Nair, M. P., Mahajan, S., Reynolds, J. L., Aalinkeel, R., & Schwartz, S. A. (2003). Immunoregulatory role of nitric oxide: implications in HIV-1 infection. Journal of Leukocyte Biology, 74(6), 889-896.
Tumor Necrosis Factor-alpha (TNF-alpha)
Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nature Reviews Immunology, 3(9), 745-756.
Mohan, T., Sharma, C., & Bhatnagar, S. (2013). Modulation of HIV-1 pathogenesis by host restriction factors and implications for therapeutic approaches. Cellular Immunology, 285(1-2), 32-49.
Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nature Reviews Immunology, 3(9), 745-756.
Calcium (Ca) and Phosphate (P) Levels
Keratin 14 (K14)
IgE Antibodies
IL-4 and IL-13
IFN-γ
https://www.researchgate.net/publication/380969109_Ocular_effects_of_eye_cosmetic_formulations
https://www.researchgate.net/publication/325933510_Eye_Cosmetic_Products_and_a_Known_Eye_Irritant
HRIPT
Interleukins
Beta carotene
MC1R
Hydroquinone
Cysteinyl dopa
Collagen I & III
MMP 8
https://www.researchgate.net/publication/377638319_Scientific_Evidence_for_the_Cosmetic_Skin_and_Hair_Benefits_of_Hemp-derived_Cannabinoids_A_Review