Anti-Wrinkle / Anti-Aging
In addition to being a natural part of aging, wrinkles also arise from external factors such as sun damage, pollution, stress, and fatigue. These elements degrade both dermal and epidermal skin components, leading to a gradual breakdown of the skin barrier. As a result, the skin surface alters, losing its youthful appearance and taking on an older, more aged look.
Why wrinkles appear
Over time, skin loses its natural moisture and the dermal-epidermal skin junction gradually loses its cohesion. As skin cells receive less nutrients, their production of structural proteins slows down. As these proteins become rare or damaged, skin loses tonicity and firmness. Expression wrinkles result from muscular action. Microcontractures generate lines and the skin between these lines distends. The areas that are most prone to changes in expression (forehead, eyebrows, lips) show these types of wrinkles. The folds of distended skin are another sign of loss in skin tone and firmness.
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| (SIRT1) | A NAD+-dependent deacetylase that regulates cellular stress responses, aging, and metabolism by deacetylating transcription factors like p53 and NF-κB. | promoting youthful skin |
| Collagen Type I | The most abundant collagen in the body, forming strong fibrils that provide tensile strength to skin, bones, tendons, and other connective tissues. | improving skin elasticity, reducing wrinkels |
| MMP-1 | An enzyme that degrades collagen type I and III in the extracellular matrix, playing a key role in tissue remodeling and skin aging. | collagen-protection claims |
| Procollagen Type I | The precursor molecule of collagen type I, synthesized in fibroblasts and processed extracellularly to form mature collagen fibers. | Anti-aging, skin-firming |
| COL1A2 | A gene encoding the alpha-2 chain of collagen type I, crucial for the synthesis and assembly of functional collagen fibrils in connective tissues. | improving skin elasticity |
Scientific Driven with our Technology:
Using our expertise in immunology and cell culture, we develop immunoassays based on ELISA principle. Using cutting edge tools like 3D tissues (some of which are OECD approved for skin / cornea irritation), we bring the human experimentation into the labs. Curating a list of research publications, we have developed a platform to test products for their biomarkers mimicking the human model to generate data to back our label claims.
Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)
Reference Research Publications:
- Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
- Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
- The anti-wrinkles properties of sodium acetylated hyaluronate
- Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
- Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
- Synthesis of Kisspeptin-Mimicking Fragments and Investigation of their Skin Anti-Aging Effects
- Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
- An Efficient Means to Mitigate Skin Inflammaging by Inhibition of the NLRP3 Inflammasome and Nfkb Pathways: A Novel Epigenetic Mechanism
Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression
Conceptualization, S.J., H.L., C.L., H.J.C., J.K. and H.J.K.; Investigation, S.Y, S.K., J.J., M.K., K.S., H.S.H., and K.-Y.P.; Writing-Original Draft Preparation, S.J.; Writing-Review & Editing, C.L. and H.J.K.; Project Administration, H.J.K.
International Journal of Molecular Science
Submission received: 6 November 2019 / Revised: 15 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019
https://doi.org/10.3390/ijms21010073
Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
Wannita Klinngam a 1, Phetploy Rungkamoltip a 1, Saowarose Thongin a, Jaruwan Joothamongkhon a, Phattharachanok Khumkhrong a, Mattaka Khongkow a, Katawut Namdee a, Surapun Tepaamorndech b, Puxvadee Chaikul c d, Mayuree Kanlayavattanakul c d, Nattaya Lourith c d, Kitiya Piboonprai a e, Uracha Ruktanonchai a, Udom Asawapirom a, Tawin Iempridee
Volume 145, January 2022, 112461
https://doi.org/10.1016/j.biopha.2021.112461
The anti‐wrinkles properties of sodium acetylated hyaluronate
Journal of cosmetology
Marie Meunier, Amandine Scandolera PhD1 Emilie Chapuis BS1
Received: 2 August 2021 Revised: 14 September 2021 Accepted: 27 September 2021
Epidermal and Dermal Hallmarks of Photoaging are Prevented by Treatment with Night Serum Containing Melatonin, Bakuchiol, and Ascorbyl Tetraisopalmitate: In Vitro and Ex Vivo Studies
Dermatology and theraphy
Published online 2020 Jan 3.
Mridvika Narda, 1 Anthony Brown,2 Béatrice Muscatelli-Groux,3 Jean A. Grimaud,3 and Corinne Granger