Acetylcholinesterase (AChE) | AChE breaks down acetylcholine in the synaptic cleft to terminate nerve signal transmission. Inhibition by organophosphate and carbamate pesticides disrupts this process, leading to overstimulation of nerves. | Pesticide Exposure |
Pesticide Metabolites | Pesticide metabolites are by-products formed when the body breaks down pesticides. These can be detected in biological samples using methods such as mass spectrometry or gas chromatography. | Exposure Confirmation |
Glutathione-S-Transferases | GSTs are enzymes that conjugate glutathione to xenobiotics, including pesticides, facilitating their detoxification and elimination. Changes in GST activity reflect the body's response to pesticide exposure. | Detoxification Response |
Carboxylesterase Activity | Carboxylesterases hydrolyze organophosphate pesticides into less toxic metabolites. Reduced enzyme activity can indicate pesticide exposure and accumulation. | Pesticide Breakdown |