Moisturizing, Hydrating and Barrier Function
Moisturizing is fundamental in the cosmetic industry, as well-hydrated skin is less likely to exhibit signs of aging. While the skin naturally ages, it also faces environmental stressors such as heat, UV rays, dust, wind, and pollution, which contribute to the gradual breakdown of the skin barrier. Various physiological processes contribute to skin dehydration over time, including changes in sebum production and reduced cellular cohesion. Without proper care and protective measures, the skin loses its firmness, leading to the formation of folds and the emergence of wrinkles
Skin Creams
Cosmetic Products
Lotions
Scrubs
Soaps
Biomarker Testing List:
| Biomarker | Scientific Pathway Details | Used to Prove Claims |
|---|---|---|
| (MMPs) | Zinc-dependent proteases that degrade extracellular matrix components, involved in tissue remodeling, inflammation, and cancer metastasis. | Reduces the appearance of wrinkles |
| IL-1, | A pro-inflammatory cytokine that activates the NF-κB and MAPK pathways, driving inflammation and immune responses. | Reduces skin inflammation |
| IL-6 | A cytokine that signals through the JAK/STAT3 pathway to regulate immune responses, inflammation, and acute-phase reactions. | Calms inflamed skin |
| TNF-α | A cytokine that activates the NF-κB and apoptotic pathways, playing a central role in inflammation and cell death. | Anti-inflammatory effect |
| collagen tripeptide | A small collagen fragment that promotes skin elasticity and repair by stimulating collagen synthesis and inhibiting its degradation. | Improves skin firmness |
| 3 (AQP3) | A water and glycerol channel protein in cell membranes that facilitates hydration and glycerol transport, important for skin moisture and wound healing. | Enhances skin hydration |
Scientific Driven with our Technology:
Using our expertise in immunology and cell culture, we develop immunoassays based on ELISA principle. Using cutting edge tools like 3D tissues (some of which are OECD approved for skin / cornea irritation), we bring the human experimentation into the labs. Curating a list of research publications, we have developed a platform to test products for their biomarkers mimicking the human model to generate data to back our label claims.
Read our Blog on Cosmetic Product Claims and other Product Claims (natural / herbal / naturopathy etc)
Reference Research Publications
Ex vivo visualization and extended release from a dissolvable microarray
The Actin-Based Motor Myosin Vb Is Crucial to Maintain Epidermal Barrier Integrity
Effects on skin metabolism (MMPs), IL-1, IL-6, TNF-α, (ROS), collagen tripeptide CTP
A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products
Regulatory Toxicology and Pharmacology
G. Reynolds, J. Reynolds, N. Gilmour, R. Cubberley, S. Spriggs, A. Aptula, K. Przybylak, S. Windebank, G. Maxwell, M.T. Baltazar
Received 29 June 2021, Revised 4 October 2021, Accepted 27 October 2021
https://doi.org/10.1016/j.yrtph.2021.105075
Mapping 2D- and 3D-distributions of metal/metal oxide nanoparticles within cleared human ex vivo skin tissues
George J. Touloumes a 1, Herdeline Ann M. Ardoña a 1, Evan K. Casalino a, John F. Zimmerman a, Christophe O. Chantre a, Dimitrios Bitounis b, Philip Demokritou b, Kevin Kit Parker
Received 28 August 2019, Revised 20 December 2019, Accepted 6 January 2020, Available online 13 January 2020, Version of Record 22 January 2020.
https://doi.org/10.1016/j.impact.2020.100208
In vitro Dermal Absorption of Hydroquinone: Protocol Validation and Applicability on Illegal Skin-Whitening Cosmetics
Bart Desmedt 1, Gamze Ates, Patricia Courselle, Jacques O De Beer, Vera Rogiers, Benoit Hendrickx, Eric Deconinck, Kristien De Paepe
Epub January 05 2017
Skin Pharmacol Physiol