Skin Irritation
Upon consideration of the expressed concerns about safety in various cosmetic formulations, skin irritation is frequently considered one of the most serious complaints. Being that the skin is in a constant state of exposure to various external and internal challenges, thus, developing and proving cosmetic products to guarantee their safety and non-irritant qualities is extremely important. Skin irritation occurs as the result of a product producing some undesirable effects on the skin, with redness, swelling, itching, or burning sensations being the salient common presentations. The causes of irritation range from irritating chemicals, fragrances, preservatives, or anything else used in the formula Some individuals might complain of related skin irritations with cosmetic applications; this is primarily so for those with sensitive skin.
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Biomarker Testing List:
Biomarker | Remarks on the Biomarker |
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IL-1α | Primary marker for skin irritation and inflammatory response. |
IL-6 | Indicates acute inflammation and immune activation. |
TNF-α | Reflects severity and extent of inflammatory response. |
COX-2 | Enzyme linked to inflammation and irritation processes. |
MMP-9 | Signals tissue damage and remodeling due to irritation. |
ROS | Marker of oxidative stress contributing to irritation. |
8-OHdG | Indicates oxidative damage to DNA during stress. |
Reference Research Publications:
https://doi.org/10.1016/j.tox.2007.05.005
Related Services
Hypoallergic
In-vitro testing assesses the potential of products to cause allergic reactions by evaluating skin cell response and measuring inflammation markers, ensuring safety for sensitive skin.
Hyperpigmentation
Tests the ability of products to reduce irritation that may worsen hyperpigmentation, using skin models to assess cellular responses and pigmentation levels.
Anti-blemishes
Evaluates the product’s effect on reducing blemish-causing inflammation and irritation, ensuring a soothing effect and promoting clearer, healthier skin.
Anti-Oxidation
Ensures that antioxidant-rich formulations are safe for the skin, protecting against irritation while defending against oxidative stress and environmental damage.