T-SkinTM / Reconstructed Human Full Thickness Skin Model
Description:
T-SkinTM is an in vitro reconstructed skin which consists of a dermal equivalent with human fibroblasts overlaid by a stratified, well differentiated epidermis derived from normal human keratinocytes cultured on an inert polycarbonate filter. This model exists at different stages of maturity
Specific markers:
Differentiation markers:
- Filaggrin
- Involucrin
- Loricrin
- Cytokeratin 10
- Transglutaminase-1
Dermal-Epidermal junction markers:
- Collagen IV, VII, XII
- Laminin V
- Perlecan
- BP antigen
Proliferation markers:
- Ki67
in vitro
Applications:
- UV Exposure
- DNA Damage
- Bacterial adhesion
- Omics
- Permeability