SkinEthicTM RHE / Reconstructed Human Epidermis

Description:

SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface. It is histologically similar to the in vivo human epidermis. Different maturities and surfaces are available. 

Specific markers:

Differentiation markers:

  • Filaggrin
  • Involucrin
  • Loricrin
  • Transglutaminase
  • Keratin 10
  • Keratin 5
  • CD44
  • Presence of different epidermal classes of lipids comprising ceramides

Dermal-Epidermal junction markers:

  • Type IV collagen
  • Laminin V (See picture)
  • Alpha6Beta4-integrin
  • BP antigen

Proliferation markers:

  • Ki67

in vitro

Applications:

  • Skin irritation
  • Skin corrosion
  • Medical devices
  • UV Exposure
  • DNA Damage
  • Bacterial adhesion
  • Omics
  • Permeability
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