The SkinEthic™ RHE-LC model is a standard epidermal model in which Langerhans cells progenitors have been integrated. During the tissue reconstruction, these immature cells have differentiated into antigen-presenting Langerhans cells expressing the specific marker CD207 (langerin). They are mostly located and evenly spread within the supra-basal epidermal layer. The SkinEthic™ RHE-LC model is therefore expected to be a useful tool for skin immune response studies.